"Supporting Brain Health in Parkinson's Disease: Why a Multi-Therapy Approach Matters,"

Part 3 of our Parkinson's Disease Series

In Part 1, we explored how Parkinson's disease is much more than a dopamine disorder. We discussed the wide range of motor and non-motor symptoms and why Parkinson's is increasingly recognised as a whole-body condition.

In Part 2, we looked beyond the diagnosis to examine the factors that may contribute to Parkinson's disease, including genetics, environmental exposures, head trauma, gut health and mitochondrial dysfunction. We also discussed the value of personalised testing to understand an individual's health picture better.

In this final article, we explore how advanced technologies may complement conventional medical care by supporting cellular health, neuroplasticity, movement and nervous system regulation.


There is currently no single therapy that can stop or reverse Parkinson's disease. However, growing research suggests that combining evidence-informed therapies may help support brain health, movement, quality of life and overall wellbeing.

At Mito Core, our approach is based on supporting the body's natural ability to adapt, repair and function. Rather than focusing on one symptom or one pathway, we combine technologies that target oxygen delivery, mitochondrial health, neuroplasticity, movement and nervous system regulation.

Photobiomodulation (Red Light Therapy)

Photobiomodulation (PBM), also known as red and near-infrared light therapy, is one of the most exciting emerging areas of research in neurodegenerative disease.

PBM works by delivering specific wavelengths of light that are absorbed by the mitochondria, the tiny structures within our cells responsible for producing energy and coordinating cellular repair. By supporting mitochondrial function, PBM may help improve cellular energy production, reduce oxidative stress, modulate inflammation and support the brain's natural ability to adapt and repair.

For people living with Parkinson's disease, there is growing interest in transcranial photobiomodulation, where a specialised red-light helmet delivers light directly to the scalp. Australian researcher Dr Ann Liebert and colleagues have been at the forefront of this work, investigating the safety and feasibility of transcranial photobiomodulation in people with Parkinson's disease. Early clinical trials have shown the therapy to be safe and suggest it may improve some motor symptoms, although larger studies are still underway to better understand its role in Parkinson's care.

At Mito Core, we believe brain health doesn't exist in isolation. That's why brain-directed therapy using a red-light helmet is complemented by full-body photobiomodulation, helping to support circulation, reduce oxidative stress and inflammation, relieve pain, assist muscle recovery and create a healthier cellular environment throughout the body.

Hyperbaric Oxygen Therapy (HBOT)

Healthy brain tissue relies on a constant supply of oxygen to function efficiently. Hyperbaric Oxygen Therapy (HBOT) increases the amount of oxygen dissolved in the blood, allowing more oxygen to reach tissues throughout the body, including the brain.

Research is investigating HBOT for its potential to:

  • Improve oxygen delivery to brain tissue

  • Support mitochondrial function and cellular energy production

  • Reduce oxidative stress and neuroinflammation

  • Promote neuroplasticity and the brain's ability to form new connections

  • Stimulate angiogenesis (the formation of new blood vessels), helping improve blood supply to tissues

  • Mobilise the body's own stem cells, supporting natural repair and regeneration processes

While HBOT is not a treatment for Parkinson's disease itself, it may complement conventional care by creating an environment where brain cells have the oxygen, nutrients and physiological support they need to function, adapt and repair more effectively.

Pulsed Electromagnetic Field (PEMF) Therapy

Every cell communicates using tiny electrical signals, including the neurons responsible for movement, balance and coordination.

PEMF therapy delivers low-frequency electromagnetic pulses that are being investigated for their ability to support cellular communication, circulation and nervous system regulation. Research suggests PEMF may influence ion channel activity, increase blood flow to nervous tissue and support healthy cellular signalling. It has also been investigated for its role in supporting cell membrane function and lipid metabolism, both of which are important for maintaining healthy neuronal membranes.

Beyond the nervous system, PEMF may help reduce pain and inflammation while supporting the health of muscles, connective tissue and bone. Many people also report improvements in sleep, relaxation, recovery and energy levels, all important foundations for maintaining brain health, mobility and quality of life.

Hypervibe G-Force

Exercise remains one of the most evidence-supported interventions for Parkinson's disease, helping maintain mobility, balance and independence.

The Hypervibe G-Force uses gentle whole-body vibration to activate muscles and challenge balance in a controlled environment. It may assist with muscle activation, posture, coordination and functional movement, making it a valuable addition to an individualised rehabilitation program.

For some people, it can also provide a safe and accessible way to keep moving when stiffness, fatigue or reduced mobility make traditional exercise more challenging.

iMRS Brain Entrainment 

Parkinson's disease affects far more than movement. Many people also experience changes in sleep, mood, energy, cognition and nervous system regulation.

The iMRS system combines Pulsed Electromagnetic Field (PEMF) therapy with brainwave entrainment to support relaxation, restorative sleep and healthy nervous system function. While research into iMRS specifically in Parkinson's disease is still emerging, therapies that help regulate the autonomic nervous system and support recovery may play an important role in a comprehensive care plan.

HOCATT

Emerging research suggests that environmental exposures may play a role in the development of Parkinson's disease for some individuals. Long-term exposure to certain pesticides, including paraquat and rotenone, as well as industrial solvents and other environmental chemicals, has been associated with an increased risk of Parkinson's disease.

If a history of environmental or occupational exposure forms part of your health story, supporting the body's natural detoxification pathways and overall resilience may be an important consideration alongside conventional medical care.

The HOCATT combines infrared heat, ozone, carbonic acid and frequency-specific microcurrents to support circulation, perspiration and overall physiological wellbeing.

Intermittent Hypoxic-Hyperoxic Training (IHHT)

Healthy brain cells rely not only on oxygen delivery, but also on the body's ability to use oxygen efficiently.

Intermittent Hypoxic-Hyperoxic Training (IHHT) alternates brief periods of lower and higher oxygen concentrations while you relax comfortably. This controlled stimulus encourages the body to adapt by improving mitochondrial efficiency, supporting cellular energy production and promoting healthy oxygen utilisation.

Research in neurological and metabolic conditions suggests IHHT may help reduce oxidative stress, improve vascular function, support healthy inflammatory responses and enhance physical resilience. While research in Parkinson's disease is still emerging, these mechanisms are highly relevant to maintaining brain health and complement therapies focused on oxygen delivery, neuroplasticity and nervous system function.

Why We Combine Therapies

Parkinson's disease affects many interconnected systems. Oxygen delivery, cellular energy, movement, inflammation, nervous system regulation and overall resilience all influence how a person feels and functions.

Rather than relying on a single therapy, Mito Core brings together complementary technologies that support these different aspects of health. Combined with appropriate medical care, exercise, nutrition and lifestyle strategies, this whole-person approach aims to create an environment where the brain and body have the best opportunity to function well.

While research into these technologies continues to evolve, our focus remains the same: supporting the person, not just the diagnosis.

About the Author

Jennifer Harrington is a naturopath with over 20 years of clinical experience and a special interest in neurodegenerative conditions. She consults at MitoCore on Mondays and Fridays, supporting patients with evidence-informed, whole-person care.

References

Parkinson's Disease

  • Armstrong MJ, Okun MS. Diagnosis and Treatment of Parkinson Disease. JAMA. 2020;323(6):548–560.

  • Bloem BR, Okun MS, Klein C. Parkinson's disease. The Lancet. 2021;397(10291):2284–2303.

  • International Parkinson and Movement Disorder Society. Clinical resources and evidence updates.

Photobiomodulation (Red Light Therapy)

  • Liebert A, Bicknell B, Laakso EL, et al. Improvements in Clinical Signs of Parkinson's Disease Using Photobiomodulation: A Prospective Proof-of-Concept Study. BMC Neurology. 2021;21:256.

  • McGee C, Liebert A, Bicknell B, et al. A Randomized Placebo-Controlled Study of a Transcranial Photobiomodulation Helmet in Parkinson's Disease: Post-Hoc Analysis of Motor Outcomes. Journal of Clinical Medicine. 2023;12(8):2846.

  • Herkes G, McGee C, Liebert A, et al. A Novel Transcranial Photobiomodulation Device to Address Motor Signs of Parkinson's Disease: A Parallel Randomised Feasibility Study. EClinicalMedicine. 2023;66:102338.

  • Bicknell B, Liebert A, Herkes G. Parkinson's Disease and Photobiomodulation: Potential for Treatment. Journal of Personalized Medicine. 2024;14(1):112.

  • Liebert A, Bicknell B, Laakso EL, et al. Improvements in Clinical Signs and Symptoms of Parkinson's Disease Using Photobiomodulation: A Five-Year Follow-Up. BMC Neurology. 2024.

Hyperbaric Oxygen Therapy (HBOT)

  • Efrati S, Ben-Jacob E. Reflections on the Hyperoxic-Hypoxic Paradox: A New Paradigm for Oxygen Therapy and Neuroplasticity. Medical Hypotheses. 2014.

  • Hadanny A, Efrati S. The Hyperoxic-Hypoxic Paradox. Biomolecules. 2020.

  • Harch PG. Hyperbaric Oxygen Therapy in Chronic Neurological Conditions. Medical Gas Research.

Pulsed Electromagnetic Field (PEMF)

  • Chen P, Li J, Telezhkin V, Gu Y, Tao M, Guo L, Song S, Dong R, Luo X, Wang Y, Liu Q, Tian W, Meng W, Hong W, Song B. Pulsed Electromagnetic Stimulation Promotes Neuronal Maturation by Up-Regulating Cholesterol Biosynthesis. Stem Cell Research & Therapy. 2025;16(1):406.

  • Piotrzkowska D, Siwak M, Adamkiewicz J, Dziki L, Majsterek I. The Therapeutic Potential of Pulsed Electromagnetic Fields (PEMF) and Low-Intensity Pulsed Ultrasound (LIPUS) in Peripheral Nerve Regeneration: A Comprehensive Review. International Journal of Molecular Sciences. 2025;26:9311.

Intermittent Hypoxic-Hyperoxic Training (IHHT)

  • Serebrovska ZO, Serebrovska TV, Kotsiuruba AV, et al. Intermittent Hypoxia–Hyperoxia Training as a Strategy for Healthy Ageing and Neuroprotection. Frontiers in Physiology. 2019.

Environmental Health

  • Tanner CM, Kamel F, Ross GW, et al. Rotenone, Paraquat and Parkinson's Disease. Environmental Health Perspectives. 2011.National Institute of Environmental Health Sciences (NIEHS). Parkinson's Disease and Environmental Factors.

Mitochondrial Health

  • Bose A, Beal MF. Mitochondrial Dysfunction in Parkinson's Disease. Journal of Neurochemistry.

  • Swerdlow RH. Mitochondria and Mitochondrial Cascades in Parkinson's Disease. Journal of Neurochemistry.

Exercise and Neuroplasticity

  • Mak MKY, Wong-Yu ISK, Shen X, Chung CLH. Long-Term Effects of Exercise and Physical Therapy in People with Parkinson Disease. Nature Reviews Neurology.

  • Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-Enhanced Neuroplasticity Targeting Motor and Cognitive Circuitry in Parkinson's Disease. The Lancet Neurology. 2013.

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Looking Beyond the Diagnosis: What May Contribute to Parkinson's Disease?